Publications

2020

 

Mamrot J, Hall NE, Lindley RA, (2020) Predicting Clinical Outcomes using Cancer Progression Associated Signatures. In preparation. Data available under CDA.

 

Steele EJ., Lindley RA, (2020) Analysis of APOBEC and ADAR deaminase-driven Riboswitch Haplotypes in COVID-19 RNA strain variants and the implications for vaccine design. In press at Research Reports. link:
http://companyofscientists.com/index.php/rr/article/view/177/163

Lindley RA, (2020) A Review of the mutational role of deaminases and the generation of a cognate molecular model to explain cancer mutation spectra. Medical Research Archives, 8(8). https://doi.org/10.18103/mra.v8i8.2177

Lindley RA, (2020) The mutagenic source and power of our own evolution. Invited chapter in “Cosmic Genetic Evolution” Eds EJ Steele and NC Wickramasinghe. In press at Advances in Genetics, 106. https://doi.org/10.1016/bs.adgen.2020.05.001

Hall NE, Mamrot J, Steele EJ, Frampton C, Read P, Bischoff R, Lindley RA, (2020) Blood and saliva-derived exomes from healthy Caucasian subjects do not display overt evidence of somatic mosaicism. Mutation Research821: 111705. https://doi.org/10.1016/j.mrfmmm.2020.111705. 

Steele, EJ,  Jiangwen Q, Lindley RA, Gorczynski RM, Tokoro G, Robert Temple R, Wickramasinghe NC, (2020) Origin of New Emergent Coronavirus and Candida Fungal Diseases – Terrestrial or Cosmic? Invited chapter in “Cosmic Genetic Evolution” Eds EJ Steele and NC Wickramasinghe. In press at Advances in Genetics, 106. https://doi.org/10.1016/bs.adgen.2020.04.002

Franklin A, Steele EJ, Lindley RA, (2020) A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases. Heliyon. 6(2): e03258. https://doi.org/10.1016/j.heliyon.2020.e03258.

Steele EJ., and Lindley RA, (2020) Regulatory T cells and co-evolution of allele-specific MHC recognition by the TCR. Scandinavian Journal of Immunology. 91: e12853. https://doi.org/10.1111/sji.12853 

2019

 

Mamrot J, Balachandran S, Steele EJ, Lindley RA, (2019) Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signaturesScandinavian Journal of Immunology, 89(5): e12760. https://doi.org/10.1111/sji.12760.

Lindley RA and Steele EJ, (2019) Deaminases and Why Mice Sometimes Lie in Immuno-Oncology Pre-Clinical TrialsAnnals of Clinical Oncology, 2(1): pp2-5. https://doi.org/10.31487/j.ACO.2019.01.001.

Steele E, Gorczynski R, Lindley RA, Liu Y, Temple R, Tokoro G, Wickramasinghe D, Wickramasingh C. (2019) Lamarck and Panspermia: Environmentally-Induced Rapid Directional Genetic Adaptation and the Effective Spread of Living Systems Throughout the CosmosProgress in Biophysics and Molecular Biology. 149: pp10-32. https://doi.org/10.1016/j.pbiomolbio.2019.08.010.

2018

Lindley RA, (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution? Edge Science, 36(1): pp16-20. ISSN 2330-4553.

Lindley RA and Steele EJ, (2018) ADAR and APOBEC editing signatures in viral RNA during acute-phase Innate Immune responses of the host-parasite relationship to FlavivirusesResearch Reports, 2(1): e1-e22. http://companyofscientists.com/index.php/rr/article/view/80/65

Lindley RA and Hall NE, (2018) APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM databaseMutation Research, 810(1): pp33-38. https://doi.org/10.1016/j.mrfmmm.2018.03.008.

 

Steele EJ, Lindley RA, (2018) Germline V repertoires: Origin, maintenance, diversificationScandinavian Journal of Immunology, 87(6): e12670. https://doi.org/10.1111/sji.12670.

2017

 

Steele EJ and Lindley RA, (2017) Origin of High Affinity Germline V Elements? Comment on Sterner, E., et al. Cell Reports, 20(1): pp1681-1691. https://doi.org/10.1016/j.celrep.2017.07.050.

Steele EJ and Lindley RA, (2017) ADAR deaminase A-to-I editing of DNA and RNA moieties of RNA:DNA hybrids has implications for the mechanism of Ig somatic hypermutationDNA Repair, 55(1): pp1-6. https://doi.org/10.1016/j.dnarep.2017.04.004.

2016

 

Lindley RA, Humbert P, Larner C, Akmeemana EH, Pendlebury CR, (2016) Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progressionCancer Medicine, 5(9): pp2629-2640. https://doi.org/10.1002/cam4.825.

2013

 

Lindley RA, (2013) The importance of codon context for understanding the Ig-like somatic hypermutation strand-biased patterns in TP53 mutations in breast cancerCancer Genetics, 206(6): pp222-6. https://doi.org/10.1016/j.cancergen.2013.05.016.

 

Lindley RA and Steele EJ, (2013) Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer. International Scholarly Research Notices: Genetics, Article ID: 921418. https://doi.org/10.1155/2013/921418.

2011

Steele EJ, Lindley RA, Weiller GW. (2011) Somatic hypermutation and the discovery of A-to-I RNA editing sites? Biochemical and Biophysical Research Communications, 414(2): p443. https://doi.org/10.1016/j.bbrc.2011.09.111.

 

Steele EJ, Williamson JF, Lester S, Stewart BJ, Millman JA, Carnegie P, Lindley RA, Pain GN, Dawkins RL. (2011) Genesis of ancestral haplotypes: RNA modifications and reverse transcription-mediated polymorphismsHuman Immunology, 72(3): pp283-293. DOI: 10.1016/j.humimm.2010.12.005.

2010

 

Steele EJ, Lindley RA, (2010) Somatic mutation patterns in non-lymphoid cancers resemble the strand biased somatic hypermutation spectra of antibody genesDNA Repair, 9(6): pp600-603. https://doi.org/10.1016/j.dnarep.2010.03.007.

2006

 

Steele EJ, Lindley RA, Wen J, Weiller GF. (2006) Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspotsDNA Repair, 5(11): pp1346-1363. https://doi.org/10.1016/j.dnarep.2006.06.002

 

Some Background Articles for General Readership

Lindley RA, (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution? Edge Science Magazine, 36(1): pp16-20. ISSN 2330-4553 

Lindley R.A, (2016) The Hunt For the Source of Mutations in Cancer. RD Wright Lecture and Medal 19 October 2016. University of Melbourne  Faculty of Medicine and Health Sciences.

https://events.unimelb.edu.au/events/7629-the-hunt-for-the-source-of-mutations-in-cancer

Lindley RA and Steele EJ, (2013) Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer. International Scholarly Research Notices: Genetics, Article ID: 921418. https://doi.org/10.1155/2013/921418.

Lindley R.A, (2012) Invited Interview. A Lifelong Passion for Science: Robyn Lindley’s Adventure Journey. GIT Laboratory Journal. 1-2: 12-14. 

https://www.laboratory-journal.com/science/life-sciences-biotech/robyn-lindley-s-adventure-journey

 

Lindley R.A, (2011) Born to Evolve: How Mutational and Epigenetic Changes Enable Adaptive Evolution. Invited Article, GIT Laboratory Journal

3-4: 2-4. https://analyticalscience.wiley.com/do/10.1002/gitlab.5424/full/

 

Lindley R.A, (2011) How Evolution Occurs: Was Lamarck Also Right? Invited Article. Edge Science Magazine 8: 6-9. Copy available on request.

 

Books for General Readership 

Lindley R.A, (2010) The Soma: How our genes really work and why that changes everything. CYO Foundation. ISBN 1451525648, Available on Books Amazon.com.

Steele E.J, Lindley R.A, and Blanden R.V,  (1998) Lamarck’s Signature: How Retrogenes are  Changing Darwin’s Natural Selection Paradigm. Allen & Unwin (Australia and Europe), Perseus Books (North America). Science Editor: Paul Davies. Available on Books Amazon.com.

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