Publications

2019

Steele EJ., and Lindley RA. (2019) Regulatory T cells and co-evolution of allele-specific MHC recognition by the TCR. Scandinavian Journal of Immunology. In Press; copy available upon request.

Lindley RA. (2019) Deaminase Targeted Somatic Mutation (TSM) Signatures: A Review Targeted Codon-Context DNA and RNA Deamination Mutations in Cancer Genome Diagnosis and Prognosis. Mutation Research. In Preparation.

Franklin A, Steele EJ, Lindley RA. (2019) A proposed reverse transcription mechanism for (CAG)n and similar expandable repeats that cause neurological and other diseases. In Press; copy available upon request.

Mamrot J, Balachandran S, Steele EJ, Lindley RA. (2019) Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signatures. Scandinavian Journal of Immunology, 89(5): e12760. DOI: 10.1111/sji.12760.

Hall NE, Mamrot J, Frampton CMA, Read P, Steele EJ, Bischof RJ, Lindley RA. (2019) Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects. BMC Medical Genomics (submitted and under review; copy available upon request).

Lindley RA and Steele EJ. (2019) Deaminases and Why Mice Sometimes Lie in Immuno-Oncology Pre-Clinical Trials. Annals of Clinical Oncology, 2(1): pp2-5. DOI: 10.31487/j.ACO.2019.01.001.

Lindley RA. (2019) Deaminase Targeted Somatic Mutation (TSM) Signatures: A Review Targeted Codon-Context DNA and RNA Deamination Mutations in Cancer Genome Diagnosis and Prognosis. Mutation Research (submitted and under review; copy available on request)

Steele E, Gorczynski R, Lindley RA, Liu Y, Temple R, Tokoro G, Wickramasinghe D, Wickramasingh C. (2019) Lamarck and Panspermia: Environmentally-Induced Rapid Directional Genetic Adaptation and the Effective Spread of Living Systems Throughout the Cosmos. Progress in Biophysics and Molecular Biology. 149: pp10-32. DOI: 10.1016/j.pbiomolbio.2019.08.010.

2018

Lindley RA. (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution?. Edge Science, 36(1): pp16-20. ISSN 2330-4553.

Lindley RA and Steele EJ. (2018) ADAR and APOBEC editing signatures in viral RNA during acute-phase Innate Immune responses of the host-parasite relationship to Flaviviruses. Research Reports, 2(1): e1-e22. DOI: 10.9777/rr.2018.10325.

Lindley RA, Hall NE. (2018) APOBEC and ADAR deaminases may cause many single nucleotide polymorphisms curated in the OMIM database. Mutation Research, 810(1): pp33-38. DOI: 10.1016/j.mrfmmm.2018.03.008.

Steele EJ, Lindley RA. (2018) Germline V repertoires: Origin, maintenance, diversification. Scandinavian Journal of Immunology, 87(6): e12670. DOI: 10.1111/sji.12670.

2017

Steele EJ and Lindley RA. (2017) Origin of High Affinity Germline V Elements? Comment on Sterner, E., et al. Cell Reports, 20(1): pp1681-1691. DOI: 10.1016/j.celrep.2017.07.050.

Steele EJ and Lindley RA. (2017) ADAR deaminase A-to-I editing of DNA and RNA moieties

of RNA:DNA hybrids has implications for the mechanism of Ig somatic hypermutation. DNA Repair, 55(1): pp1-6. DOI: 10.1016/j.dnarep.2017.04.004.

2016

Lindley RA, Humbert P, Larner C, Akmeemana EH, Pendlebury CR. (2016) Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Cancer Medicine, 5(9): pp2629-2640. DOI: 10.1002/cam4.825.

2013

Lindley RA. (2013) The importance of codon context for understanding the Ig-like somatic hypermutation strand-biased patterns in TP53 mutations in breast cancer.

Cancer Genetics, 206(6): pp222-6. DOI: 10.1016/j.cancergen.2013.05.016.

Lindley RA and Steele EJ. (2013) Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer. International Scholarly Research Notices: Genetics, Article ID: 921418. DOI: 10.1155/2013/921418.

2011

Steele EJ, Lindley RA, Weiller GW. (2011) Somatic hypermutation and the discovery of A-to-I RNA editing sites?. Biochemical and Biophysical Research Communications, 414(2): p443. DOI: 10.1016/j.bbrc.2011.09.111.

Steele EJ, Williamson JF, Lester S, Stewart BJ, Millman JA, Carnegie P,

Lindley RA, Pain GN, Dawkins RL. (2011) Genesis of ancestral haplotypes: RNA modifications and reverse transcription-mediated polymorphisms. Human Immunology, 72(3): pp283-293. DOI: 10.1016/j.humimm.2010.12.005.

2010

Steele EJ, Lindley RA. (2010) Somatic mutation patterns in non-lymphoid cancers resemble the strand biased somatic hypermutation spectra of antibody genes. DNA Repair, 9(6): pp600-603. DOI: 10.1016/j.dnarep.2010.03.007.

2006

Steele EJ, Lindley RA, Wen J, Weiller GF. (2006) Computational analyses show A-to-G mutations correlate with nascent mRNA hairpins at somatic hypermutation hotspots. DNA Repair, 5(11): pp1346-1363. DOI: 10.1016/j.dnarep.2006.06.002.

Some Background Articles for General Readership

Lindley RA. (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution?. Edge Science Magazine, 36(1): pp16-20. ISSN 2330-4553 Copy available on request.

Lindley, R.A. (2016) The Hunt For the Source of Mutations in Cancer. RD Wright Lecture and Medal 19 October 2016. University of Melbourne Faculty of Medicine and Health Sciences.

https://events.unimelb.edu.au/events/7629-the-hunt-for-the-source-of-mutations-in-cancer

Lindley, R.A. (2012) Invited Interview. A Lifelong Passion for Science: Robyn Lindley’s Adventure Journey. GIT Laboratory Journal. 1-2: 12-14.

https://www.laboratory-journal.com/science/life-sciences-biotech/robyn-lindley-s-adventure-journey

Lindley, R.A. (2011) Born to Evolve: How Mutational and Epigenetic Changes Enable Adaptive Evolution. Invited Article, GIT Laboratory Journal.

3-4: 2-4.

https://www.laboratory-journal.com/science/life-sciences-biotech/how-mutational-and-epigenetic-changes-enable-adaptive-evolution

Lindley, R.A. (2011) How Evolution Occurs: Was Lamarck Also Right? Invited Article. Edge Science Magazine 8: 6-9. Copy available on request.

Books for General Readership

Lindley, R.A. (2010). The Soma: How our genes really work and why that changes everything. CYO Foundation,ISBN 1451525648, Available on Books Amazon.com.

Steele, E.J., Lindley, R.A., and Blanden, R.V. (1998). Lamarck’s Signature: How Retrogenes are Changing Darwin’s Natural Selection Paradigm. Allen & Unwin (Australia and Europe), Perseus Books (North America). Science Editor: Paul Davies. Available on Books Amazon.com.

Pharma R&D

Pharma R&D

Pharma R&D

Pharma R&D

Publications

Mamrot J, Balachandran S, Steele EJ, Lindley RA. (2019) Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signatures. Scandinavian Journal of Immunology, 89(5): e12760. DOI: 10.1111/sji.12760.

Hall NE, Mamrot J, Frampton CMA, Read P, Steele EJ, Bischof RJ, Lindley RA. (2019) Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects. BMC Medical Genomics (submitted and under review; copy available upon request).

Lindley RA and Steele EJ. (2019) Deaminases and Why Mice Sometimes Lie in Immuno-Oncology Pre-Clinical Trials. Annals of Clinical Oncology, 2(1): pp2-5. DOI: 10.31487/j.ACO.2019.01.001.

Lindley RA. (2019) Deaminase Targeted Somatic Mutation (TSM) Signatures: A Review Targeted Codon-Context DNA and RNA Deamination Mutations in Cancer Genome Diagnosis and Prognosis. Mutation Research (submitted and under review; copy available on request)

2018

Lindley RA. (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution?. Edge Science, 36(1): pp16-20. ISSN 2330-4553.

Lindley RA and Steele EJ. (2018) ADAR and APOBEC editing signatures in viral RNA during acute-phase Innate Immune responses of the host-parasite relationship to Flaviviruses. Research Reports, 2(1): e1-e22. DOI: 10.9777/rr.2018.10325.

Steele EJ and Lindley RA. (2017) Origin of High Affinity Germline V Elements? Comment on Sterner, E., et al. Cell Reports, 20(1): pp1681-1691. DOI: 10.1016/j.celrep.2017.07.050.

Lindley RA and Steele EJ. (2013) Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer. International Scholarly Research Notices: Genetics, Article ID: 921418. DOI: 10.1155/2013/921418.

2011

Publications

Mamrot J, Balachandran S, Steele EJ, Lindley RA. (2019) Molecular model linking Th2 polarized M2 tumour-associated macrophages with deaminase-mediated cancer progression mutation signatures. Scandinavian Journal of Immunology, 89(5): e12760. DOI: 10.1111/sji.12760.

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Hall NE, Mamrot J, Frampton CMA, Read P, Steele EJ, Bischof RJ, Lindley RA. (2019) Deaminase associated single nucleotide variants in blood and saliva-derived exomes from healthy subjects. BMC Medical Genomics (submitted and under review; copy available upon request).

​

Lindley RA and Steele EJ. (2019) Deaminases and Why Mice Sometimes Lie in Immuno-Oncology Pre-Clinical Trials. Annals of Clinical Oncology, 2(1): pp2-5. DOI: 10.31487/j.ACO.2019.01.001.

​

Lindley RA. (2019) Deaminase Targeted Somatic Mutation (TSM) Signatures: A Review Targeted Codon-Context DNA and RNA Deamination Mutations in Cancer Genome Diagnosis and Prognosis. Mutation Research (submitted and under review; copy available on request)

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2018

​

Lindley RA. (2018) A New Treaty Between Disease and Evolution: Are deaminases the “universal mutators” responsible for our own evolution?. Edge Science, 36(1): pp16-20. ISSN 2330-4553.

​

Lindley RA and Steele EJ. (2018) ADAR and APOBEC editing signatures in viral RNA during acute-phase Innate Immune responses of the host-parasite relationship to Flaviviruses. Research Reports, 2(1): e1-e22. DOI: 10.9777/rr.2018.10325.

​

Steele EJ and Lindley RA. (2017) Origin of High Affinity Germline V Elements? Comment on Sterner, E., et al. Cell Reports, 20(1): pp1681-1691. DOI: 10.1016/j.celrep.2017.07.050.

​

Lindley RA and Steele EJ. (2013) Critical analysis of strand-biased somatic mutation signatures in TP53 versus Ig genes, in genome -wide data and the etiology of cancer. International Scholarly Research Notices: Genetics, Article ID: 921418. DOI: 10.1155/2013/921418.

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2011

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