THE PLATFORM
The Immune Fitness Profile
A proprietary AI-enabled genomic analysis platform that interprets deaminase-driven mutation dynamics, from dual sequencing of tumour tissue and matched germline to a personalised result scored against a large patient reference database.
01
Sequence
Dual sequencing of tumour tissue and matched germline (blood) samples.
02
Analyse
41,162 genomic metrics extracted via proprietary AI and machine-learning algorithms.
03
Attribute
The likely deaminase source of each mutation identified in Targeted Somatic Mutation format.
04
Report
Personalised prediction scored against a reference database of 20,000+ patient profiles.
PLATFORM ARCHITECTURE
CRIS, the Codon Reference Information System
Beyond the patents, GMDx has built the operational technology stack: a cloud-deployable implementation with proprietary AI and ML pipelines, a 20,000+ patient reference database, and an established processor for codon-context mutational analysis. The architecture supports laboratory-developed test and companion-diagnostic regulatory pathways.
WHY IT IS FOUNDATIONAL
Biological causality, not pattern recognition.
GMDx links sequence data to amino-acid structure through codon-context analysis, identifying the mutation source (APOBEC, AID, ADAR) with strand-bias and sequence-context resolution. This mechanistic attribution layer is what AI genomics models, sequencing pipelines, precision diagnostics and drug developers do not have, and what the GMDx methods uniquely provide.
